Bicellar systems as new delivery strategy for topical application of flufenamic acid.

@article{Rubio2013BicellarSA,
  title={Bicellar systems as new delivery strategy for topical application of flufenamic acid.},
  author={L. Rubio and C. Alonso and G. Rodr{\'i}guez and M. Cocera and C. López-Iglesias and L. Coderch and A. de la Maza and J. Parra and O. L{\'o}pez},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={444 1-2},
  pages={
          60-9
        }
}
In this work, bicellar systems, bilayered disc-shaped nanoaggregates formed in water by phospholipids, are proposed as a novel strategy for delivery of the anti-inflammatory flufenamic acid (FFA) to the skin. A comparative percutaneous penetration study of this drug in bicellar systems and other vehicles was conducted. The effects induced on the skin by the application of FFA in the different vehicles were analyzed by attenuated total reflectance-fourier transform infrared (ATR-FTIR… Expand
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References

SHOWING 1-10 OF 54 REFERENCES
Effect of bicellar systems on skin properties.
TLDR
The results show that bicelles increase the TEWL, the skin elastic parameters and, decrease skin hydration without promoting local signs of irritation and without affecting the SC lipid microstructure. Expand
Bicellar systems for in vitro percutaneous absorption of diclofenac.
TLDR
These bicellar systems have potential enhancement or retardant effects on percutaneous absorption that result in an interesting strategy, which may be used in future drug delivery applications, depending on their physicochemical parameters and on the application conditions. Expand
Structural effects of flufenamic acid in DPPC/DHPC bicellar systems
The effect of the anti-inflammatory flufenamic acid (FFA) in dipalmitoylphosphatidylcholine (DPPC)/dihexanoylphosphatidylcholine (DHPC) bicellar systems has been investigated. For this purpose, aExpand
Application of bicellar systems on skin: diffusion and molecular organization effects.
TLDR
Analysis of the lipid organization in terms of chain conformational order and lateral packing shows that the use of bicelles hampers the fluidification of SC lipids with temperature and leads to a lateral packing corresponding to a stable hexagonal phase. Expand
Bicellar systems as modifiers of skin lipid structure.
TLDR
Dynamic light scattering and freeze fracture electron microscopy techniques showed that bicellar systems formed by DPPC and DHPC can promote the formation of new structures in the SC lipid domains, which indicates the passage of lipids from b icelles through the SC layers and also a possible interaction of these lipids with the SC lipids. Expand
Penetration and growth of DPPC/DHPC bicelles inside the stratum corneum of the skin.
TLDR
The bicellar system used is suitable to penetrate the skin SC and to reinforce the intercellular lipid areas, constituting a promising tool for skin applications. Expand
The Effect of Liposomes on Skin Barrier Structure
TLDR
‘In vivo’ stripping technique to evaluate the percutaneous absorption of sodium fluorescein (NaFl) vehiculized in two different liposome preparations formed by phosphatidylcholine and lipids mimicking the stratum corneum suggests a greater reservoir capacity of SC when similar lipid composition formulation is applied. Expand
Effects of various vehicles on the penetration of flufenamic acid into human skin.
TLDR
The effect of various vehicles on the penetration of flufenamic acid into excised human skin was investigated and the effects of penetration enhancers clearly illustrated that liberation experiments do not predict the situation in the skin, but make experiments with a biological barrier essential. Expand
Lipid nanostructures: self-assembly and effect on skin properties.
TLDR
The results revealed that nanostructures with similar assembly but different composition caused different effects on the skin parameters, and samples containing DMPC affected the barrier function to a greater extent than systems containing DPPC. Expand
Synergistic effect of isopropyl myristate and glyceryl monocaprylate on the skin permeation of pentazocine.
TLDR
Results indicate that the synergistic effects of IPM and GEFA-C(8) enhance transdermal permeation of PTZ by disrupting SC lipids. Expand
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