BicaudalD Actively Regulates Microtubule Motor Activity in Lipid Droplet Transport

@article{Larsen2008BicaudalDAR,
  title={BicaudalD Actively Regulates Microtubule Motor Activity in Lipid Droplet Transport},
  author={Kristoffer Larsen and Jing Xu and Silvia Cermelli and Zhanyong Shu and Steven P. Gross},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={105 - 111}
}
BACKGROUND A great deal of sub-cellular organelle positioning, and essentially all minus-ended organelle transport, depends on cytoplasmic dynein, but how dynein's function is regulated is not well understood. BicD is established to play a critical role in mediating dynein function-loss of BicD results in improperly localized nuclei, mRNA particles, and a dispersed Golgi apparatus-however exactly what BicD's role is remains unknown. Nonetheless, it is widely believed that BicD may act to tether… CONTINUE READING

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