Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection.

@article{Dharan2017BicaudalDF,
  title={Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection.},
  author={A. Giri Dharan and Silvana Opp and Omar Abdel-Rahim and Sevnur Komurlu Keceli and Sabrina Q. Imam and Judd F. Hultquist and Edward M Campbell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 50},
  pages={
          E10707-E10716
        }
}
Numerous viruses, including HIV-1, exploit the microtubule network to traffic toward the nucleus during infection. Although numerous studies have observed a role for the minus-end microtubule motor dynein in HIV-1 infection, the mechanism by which the viral core containing the viral genome associates with dynein and induces its perinuclear trafficking has remained unclear. Here, we report that the dynein adapter protein bicaudal D2 (BICD2) is able to interact with HIV-1 viral cores in target… CONTINUE READING
BETA