Bicarbonate supplementation slows progression of CKD and improves nutritional status.

  title={Bicarbonate supplementation slows progression of CKD and improves nutritional status.},
  author={Ione de Brito-Ashurst and Mira Varagunam and Martin J. Raftery and Muhammad Magdi Yaqoob},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={20 9},
Bicarbonate supplementation preserves renal function in experimental chronic kidney disease (CKD), but whether the same benefit occurs in humans is unknown. Here, we randomly assigned 134 adult patients with CKD (creatinine clearance [CrCl] 15 to 30 ml/min per 1.73 m(2)) and serum bicarbonate 16 to 20 mmol/L to either supplementation with oral sodium bicarbonate or standard care for 2 yr. The primary end points were rate of CrCl decline, the proportion of patients with rapid decline of CrCl (>3… CONTINUE READING
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