Bicarbonate directly modulates activity of chemosensitive neurons in the retrotrapezoid nucleus.

KEY POINTS Changes in CO2 result in corresponding changes in both H+ and HCO3- and despite evidence that HCO3- can function as an independent signalling molecule, there is little evidence suggesting HCO3- contributes to respiratory chemoreception. We show that HCO3- directly activates chemosensitive retrotrapezoid nucleus (RTN) neurons. Identifying all… CONTINUE READING