Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.

@article{Gebremariam2016BicarbonateCO,
  title={Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.},
  author={Teclegiorgis Gebremariam and Lin Lin and Mingfu Liu and Dimitrios P Kontoyiannis and Samuel William French and John E. Edwards and Scott G. Filler and Ashraf S Ibrahim},
  journal={The Journal of clinical investigation},
  year={2016},
  volume={126 6},
  pages={
          2280-94
        }
}
Patients with diabetic ketoacidosis (DKA) are uniquely predisposed to mucormycosis, an angioinvasive fungal infection with high mortality. Previously, we demonstrated that Rhizopus invades the endothelium via binding of fungal CotH proteins to the host receptor GRP78. Here, we report that surface expression of GRP78 is increased in endothelial cells exposed to physiological concentrations of β-hydroxy butyrate (BHB), glucose, and iron that are similar to those found in DKA patients… CONTINUE READING
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