Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.

@article{Poulsen1994BicarbonateCA,
  title={Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.},
  author={J\orgen Hedemark Poulsen and Horst Fischer and Beate Illek and Terry E. Machen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 12},
  pages={5340-4}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl- channel regulated by protein kinase A. The most common mutation in cystic fibrosis (CF), deletion of Phe-508 (delta F508-CFTR), reduces Cl- secretion, but the fatal consequences of CF have been difficult to rationalize solely in terms of this defect. The aim of this study… CONTINUE READING