Bicarbonate and the renal regulation of acid base balance.

@article{Pitts1946BicarbonateAT,
  title={Bicarbonate and the renal regulation of acid base balance.},
  author={Robert F. Pitts and William D. Lotspeich},
  journal={The American journal of physiology},
  year={1946},
  volume={147},
  pages={
          138-54
        }
}
Under the usual circumstance of ingestion of an acid ash diet the normal individual is faced with a deficit of available base. Those stores of circulating bicarbonate which enter the glomerular filtrate along with other crystalloids of the plasma are carefully conserved; only minute amounts are lost in the urine. But when an alkaline ash diet is ingested or sodium bicarbonate is administered, supplies of available base exceed the needs of the body, and the excess is excreted in the urine as… CONTINUE READING

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