Bicarbonate/CO2, an effector of capacitation, induces a rapid and reversible change in the lipid architecture of boar sperm plasma membranes.

@article{Harrison1996BicarbonateCO2AE,
  title={Bicarbonate/CO2, an effector of capacitation, induces a rapid and reversible change in the lipid architecture of boar sperm plasma membranes.},
  author={Robin A P Harrison and Philip J. Ashworth and Norman G. Miller},
  journal={Molecular reproduction and development},
  year={1996},
  volume={45 3},
  pages={378-91}
}
Bicarbonate/CO2 is believed to be the key in vitro effector of sperm capacitation, a process which induces major changes in the sperm plasma membrane in preparation for fertilization. In a flow cytometric study, we examined the effect of bicarbonate on boar spermatozoa using merocyanine, an impermeant lipophilic probe which binds to plasma membranes with increasing affinity as their lipid components become more disordered. We found that bicarbonate causes a rapid increase in the ability of live… CONTINUE READING
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