Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1α

  title={Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1$\alpha$},
  author={Kuan-Chou Chen and Chang-Rong Chen and Chang-Yu Chen and Kai-Yi Tzou and Chiung-Chi Peng and Robert Y. Peng},
  journal={International Journal of Molecular Sciences},
  • Kuan-Chou Chen, Chang-Rong Chen, +3 authors R. Y. Peng
  • Published 1 May 2020
  • Medicine, Chemistry
  • International Journal of Molecular Sciences
Combined androgen blockade using bicalutamide (Bic) is a therapeutic choice for treating prostate cancer (PCa). However, even at regular clinical dosages, Bic frequently shows adverse effects associated with cardiovascular and renal damage. Previously, we found that Bic selectively damaged mesangial cells compared to tubular cells and in an in vivo rat model, we also found renal damage caused by Bic. In the present study, a rat mesangial cell model was used to further the investigation. Results… Expand
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Renal Damaging Effect Elicited by Bicalutamide Therapy Uncovered Multiple Action Mechanisms As Evidenced by the Cell Model
  • Chiung Chi Peng, Chang-Yu Chen, +4 authors R. Y. Peng
  • Medicine
  • Scientific Reports
  • 2019
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