Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1α

@article{Chen2020BicalutamideER,
  title={Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1$\alpha$},
  author={Kuan-Chou Chen and Chang-Rong Chen and Chang-Yu Chen and Kai-Yi Tzou and Chiung-Chi Peng and Robert Y. Peng},
  journal={International Journal of Molecular Sciences},
  year={2020},
  volume={21}
}
  • Kuan-Chou Chen, Chang-Rong Chen, +3 authors R. Y. Peng
  • Published 1 May 2020
  • Medicine, Chemistry
  • International Journal of Molecular Sciences
Combined androgen blockade using bicalutamide (Bic) is a therapeutic choice for treating prostate cancer (PCa). However, even at regular clinical dosages, Bic frequently shows adverse effects associated with cardiovascular and renal damage. Previously, we found that Bic selectively damaged mesangial cells compared to tubular cells and in an in vivo rat model, we also found renal damage caused by Bic. In the present study, a rat mesangial cell model was used to further the investigation. Results… Expand
Construction and Verification of a Hypoxia-Related 4-lncRNA Model for Prediction of Breast Cancer
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This study proves that hypoxia-related long non-coding RNAs serve as accurate indicators of poor prognosis and short overall survival, and are likely to act as potential targets for future cancer therapy. Expand

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