Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples.

@article{Chen2012BiasesAE,
  title={Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples.},
  author={Xiaowei Chen and Jennifer Beth Listman and Frank J. Slack and Joel Gelernter and Hongyu Zhao},
  journal={Genetic epidemiology},
  year={2012},
  volume={36 6},
  pages={
          549-60
        }
}
Next-generation sequencing is widely used to study complex diseases because of its ability to identify both common and rare variants without prior single nucleotide polymorphism (SNP) information. Pooled sequencing of implicated target regions can lower costs and allow more samples to be analyzed, thus improving statistical power for disease-associated variant detection. Several methods for disease association tests of pooled data and for optimal pooling designs have been developed under… CONTINUE READING

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