Biased signalling is an essential feature of TLR4 in glioma cells.

@article{Zeuner2016BiasedSI,
  title={Biased signalling is an essential feature of TLR4 in glioma cells.},
  author={Marie-Theres Zeuner and Carmen L Kr{\"u}ger and Katharina Volk and K Bieback and Graeme S Cottrell and Mike Heilemann and Darius Widera},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1863 12},
  pages={
          3084-3095
        }
}
A distinct feature of the Toll-like receptor 4 (TLR4) is its ability to trigger both MyD88-dependent and MyD88-independent signalling, culminating in activation of pro-inflammatory NF-κB and/or the antiviral IRF3. Although TLR4 agonists (lipopolysaccharides; LPSs) derived from different bacterial species have different endotoxic activity, the impact of LPS chemotype on the downstream signalling is not fully understood. Notably, different TLR4 agonists exhibit anti-tumoural activity in animal… CONTINUE READING
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