Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles.

@article{Lachance2014BiasedGC,
  title={Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles.},
  author={Joseph Lachance and Sarah A Tishkoff},
  journal={American journal of human genetics},
  year={2014},
  volume={95 4},
  pages={408-20}
}
Gene conversion results in the nonreciprocal transfer of genetic information between two recombining sequences, and there is evidence that this process is biased toward G and C alleles. However, the strength of GC-biased gene conversion (gBGC) in human populations and its effects on hereditary disease have yet to be assessed on a genomic scale. Using high-coverage whole-genome sequences of African hunter-gatherers, agricultural populations, and primate outgroups, we quantified the effects of GC… CONTINUE READING
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