Biased gene conversion and the evolution of mammalian genomic landscapes.

@article{Duret2009BiasedGC,
  title={Biased gene conversion and the evolution of mammalian genomic landscapes.},
  author={Laurent Duret and Nicolas Galtier},
  journal={Annual review of genomics and human genetics},
  year={2009},
  volume={10},
  pages={
          285-311
        }
}
  • Laurent Duret, Nicolas Galtier
  • Published 2009
  • Biology, Medicine
  • Annual review of genomics and human genetics
  • Recombination is typically thought of as a symmetrical process resulting in large-scale reciprocal genetic exchanges between homologous chromosomes. Recombination events, however, are also accompanied by short-scale, unidirectional exchanges known as gene conversion in the neighborhood of the initiating double-strand break. A large body of evidence suggests that gene conversion is GC-biased in many eukaryotes, including mammals and human. AT/GC heterozygotes produce more GC- than AT-gametes… CONTINUE READING

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