Biased gene conversion: implications for genome and sex evolution.

@article{Marais2003BiasedGC,
  title={Biased gene conversion: implications for genome and sex evolution.},
  author={Gabriel A.B. Marais},
  journal={Trends in genetics : TIG},
  year={2003},
  volume={19 6},
  pages={330-8}
}
Classical genetic studies show that gene conversion can favour some alleles over others. Molecular experiments suggest that gene conversion could favour GC over AT basepairs, leading to the concept of biased gene conversion towards GC (BGC(GC)). The expected consequence of such a process is the GC-enrichment of DNA sequences under gene conversion. Recent genomic work suggests that BGC(GC) affects the base composition of yeast, invertebrate and mammalian genomes. Hypotheses for the mechanisms… CONTINUE READING
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