Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice

@article{Malynn1990BiasedEO,
  title={Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice},
  author={Barbara A Malynn and George D. Yancopoulos and John E. Barth and Constantin A. Bona and Frederick W Alt},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={171},
  pages={843 - 859}
}
We have previously demonstrated a dramatic preference for utilization of the most JH-proximal VH gene segments in the newborn liver versus adult spleen. We now examine in detail the relative expression of different VH gene families throughout ontogeny and in immunodeficient mice to gain insight into factors that cause the shift in VH usage. We find that the… CONTINUE READING