Biased estimators of quantitative trait locus heritability and location in interval mapping

@article{Bogdan2005BiasedEO,
  title={Biased estimators of quantitative trait locus heritability and location in interval mapping},
  author={Malgorzata Bogdan and Rebecca W. Doerge},
  journal={Heredity},
  year={2005},
  volume={95},
  pages={476-484}
}
In many empirical studies, it has been observed that genome scans yield biased estimates of heritability, as well as genetic effects. It is widely accepted that quantitative trait locus (QTL) mapping is a model selection procedure, and that the overestimation of genetic effects is the result of using the same data for model selection as estimation of parameters. There are two key steps in QTL modeling, each of which biases the estimation of genetic effects. First, test procedures are employed… CONTINUE READING
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