Biased distribution of inverted and direct Alus in the human genome: implications for insertion, exclusion, and genome stability.

@article{Stenger2001BiasedDO,
  title={Biased distribution of inverted and direct Alus in the human genome: implications for insertion, exclusion, and genome stability.},
  author={Judith E. Stenger and Kirill S Lobachev and Dmitry A Gordenin and Thomas A. Darden and Jerzy Jurka and Michael A. Resnick},
  journal={Genome research},
  year={2001},
  volume={11 1},
  pages={12-27}
}
Alu sequences, the most abundant class of large dispersed DNA repeats in human chromosomes, contribute to human genome dynamics. Recently we reported that long inverted repeats, including human Alus, can be strong initiators of genetic change in yeast. We proposed that the potential for interactions between adjacent, closely related Alus would influence their stability and this would be reflected in their distribution. We have undertaken an extensive computational analysis of all Alus (the… CONTINUE READING