Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL

@article{Reichel2001BiasedDO,
  title={Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL},
  author={M. Reichel and E. Gillert and S. Angermüller and J. P. Hensel and F. Heidel and Martin Lode and T. Leis and A. Biondi and O. Haas and S. Strehl and E. Panzer-Gr{\"u}mayer and F. Griesinger and J. Beck and J. Greil and G. Fey and F. Uckun and R. Marschalek},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={2900-2907}
}
Derivative chromosomes of 40 patients diagnosed with t(4;11) acute lymphoblastic leukemia (ALL) were analysed on the genomic DNA level. Chromosomal breakpoints were identified in most cases within the known breakpoint cluster regions of the involved MLL and AF4 genes. Due to our current knowledge of the primary DNA sequences of both breakpoint cluster regions, specific features were identified at the chromosomal fusion sites, including deletions, inversions and duplications of parental DNA… Expand
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TLDR
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TLDR
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TLDR
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