Biased allelic expression in human primary fibroblast single cells.

@article{Borel2015BiasedAE,
  title={Biased allelic expression in human primary fibroblast single cells.},
  author={Christelle Borel and Pedro Gabriel Ferreira and Federico Andrea Santoni and Olivier Delaneau and Alexandre Fort and Konstantin Yu Popadin and Marco Garieri and Emilie Falconnet and Pascale G Ribaux and Michel Guipponi and Ismael Padioleau and Piero Carninci and Emmanouil T. Dermitzakis and Stylianos E. Antonarakis},
  journal={American journal of human genetics},
  year={2015},
  volume={96 1},
  pages={70-80}
}
The study of gene expression in mammalian single cells via genomic technologies now provides the possibility to investigate the patterns of allelic gene expression. We used single-cell RNA sequencing to detect the allele-specific mRNA level in 203 single human primary fibroblasts over 133,633 unique heterozygous single-nucleotide variants (hetSNVs). We observed that at the snapshot of analyses, each cell contained mostly transcripts from one allele from the majority of genes; indeed, 76.4% of… CONTINUE READING
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