Biased Signaling of Protease-Activated Receptors

  title={Biased Signaling of Protease-Activated Receptors},
  author={Peishen Zhao and Matthew D. Metcalf and Nigel W Bunnett},
  booktitle={Front. Endocrinol.},
In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain, and repair mechanisms. Certain proteases can signal to cells by cleaving protease-activated receptors (PARs), a family of four G protein-coupled receptors. PARs are expressed by almost all cell types, control important physiological and disease-relevant processes, and are an… CONTINUE READING
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