Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts.

@article{Huot2002BiallelicMI,
  title={Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts.},
  author={Thomas J. G. Huot and Janice Rowe and Mark Harland and Sarah Drayton and Sharon Brookes and Chandra Gooptu and Patricia E. Purkis and Mike Fried and V{\'e}ronique Bataille and Eiji Hara and Julia A. Newton-Bishop and Gordon G Peters},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 23},
  pages={8135-43}
}
The INK4a/ARF tumor suppressor locus is implicated in the senescence-like growth arrest provoked by oncogenic Ras in primary cells. INK4a and ARF are distinct proteins encoded by transcripts in which a shared exon is decoded in alternative reading frames. Here we analyze dermal fibroblasts (designated Q34) from an individual carrying independent missense mutations in each copy of the common exon. Both mutations alter the amino acid sequence of INK4a and functionally impair the protein, although… CONTINUE READING