Biallelic deletion and loss of expression analysis of genes at FRA2G common fragile site in tumor-derived cell lines.

  title={Biallelic deletion and loss of expression analysis of genes at FRA2G common fragile site in tumor-derived cell lines.},
  author={Zaira M Limongi and Angela Curatolo and Franca Pelliccia and Angela Rocchi},
  journal={Cancer genetics and cytogenetics},
  volume={161 2},
6 Citations

Gene microarray analysis of human renal cell carcinoma: The effects of HDAC inhibition and retinoid treatment

Results show that treatment of RCC with cRA and/or SAHA increases the expression of several genes and gene families that result in reduced cell proliferation, and combined treatment with both SAHA and cRA induced several transcripts with known anti-cancer/immunomodulatory effects.

Histone deacetylase (HDAC) inhibitor treatments can augment the anti-tumor effects of retinoids in renal cancer cells. We studied the effects of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) and 13-cis retinoic acid (cRA) on two human renal cell carcinoma

  • 2008



Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells

The hypothesis that common fragile sites and their associated genes are, in general, unstable in some cancer cells is supported, including FRAXB, which is not associated with any known tumor suppressor genes or activity.

Characterization of the common fragile site FRA9E and its potential role in ovarian cancer

Evidence is provided to suggest that instability within FRA9E may play an important role in the development of ovarian cancer and lends further support for the hypothesis that CFSs may be causally related to cancer.

Characterization of the human common fragile site FRA2G.

A role for common fragile site induction in amplification of human oncogenes.

Chromosomal fragile site FRA16D and DNA instability in cancer.

The FRA16D chromosomal fragile site locus has a role to play in predisposing DNA sequences within and adjacent to the fragile site to DNA instability (such as deletion or translocation), which could lead to or be associated with neoplasia.

Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors

FRA6F may represent a landmark for the identification and cloning of genes involved in senescence, leukemia, cancer and schizophrenia, and it is found that tight clusters of stem-loop structures were localized exclusively in the two regions with greater frequency of breakage.

FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.

To the knowledge, this is the first molecular characterization of an in vivo viral integration event within a confirmed fragile site region, supporting previous cytogenetic observations linking viral integration sites and fragile sites.

Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I.

It is shown that the region containing the PIP gene is duplicated in the breast carcinoma cell line T47D, providing the first evidence that this amplification mechanism can be initiated in vivo by fragile site activation.

A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D.

Preliminary data to suggest that P1-derived bacterial artificial chromosome clones from the contig lie on both sides of FRA16D, the common fragile site in the loss of 16q23.2 material in various cancer types, is suggested.

Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site.

  • D. MishmarA. Rahat B. Kerem
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
These unusual DNA characteristics are possibly intrinsic properties of common fragile sites that may affect their replication and condensation as well as organization, and may lead to fragility.