Biallelic deletion 13q14.3 in patients with chronic lymphocytic leukemia: cytogenetic, FISH and clinical studies.

@article{Chena2008BiallelicD1,
  title={Biallelic deletion 13q14.3 in patients with chronic lymphocytic leukemia: cytogenetic, FISH and clinical studies.},
  author={C. L. Philip Chena and Julio C S{\'a}nchez Avalos and Raimundo Fernando Bezares and Guillermo Arrossagaray and Karina Turd{\'o} and Alicia Bistmans and Irma Rosa Slavutsky},
  journal={European journal of haematology},
  year={2008},
  volume={81 2},
  pages={94-9}
}
BACKGROUND AND OBJECTIVE Monoallelic deletion of 13q14.3 (13q14x1) is the most common abnormality in chronic lymphocytic leukemia (CLL). As a sole alteration, it predicts a favorable outcome. Biallelic 13q14.3 (13q14x2) deletion or concomitant 13q14x1/13q14x2 has been scarcely evaluated in the literature. We present the clinical, cytogenetic and fluorescence in situ hybridization (FISH) analysis of six CLL patients with normal karyotypes and 13q14x2 and their comparison to cases with 13q14x1 as… CONTINUE READING
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