Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.

@article{Osato1999BiallelicAH,
  title={Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.},
  author={Motomi Osato and Norio Asou and E M Abdalla and Koyu Hoshino and Hidetoshi Yamasaki and Toshiya Okubo and Hitoshi Suzushima and Kiyoshi Takatsuki and Tomohiko Kanno and Katsuya Shigesada and Yoshikazu Ito},
  journal={Blood},
  year={1999},
  volume={93 6},
  pages={1817-24}
}
The AML1 gene encoding the DNA-binding alpha-subunit in the Runt domain family of heterodimeric transcription factors has been noted for its frequent involvement in chromosomal translocations associated with leukemia. Using reverse transcriptase-polymerase chain reaction (RT-PCR) combined with nonisotopic RNase cleavage assay (NIRCA), we found point mutations of the AML1 gene in 8 of 160 leukemia patients: silent mutations, heterozygous missense mutations, and biallelic nonsense or frameshift… CONTINUE READING
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