BiP forms stable complexes with unassembled subunits of the acetylcholine receptor in transfected COS cells and in C2 muscle cells

@article{Forsayeth1992BiPFS,
  title={BiP forms stable complexes with unassembled subunits of the acetylcholine receptor in transfected COS cells and in C2 muscle cells},
  author={John R. Forsayeth and Y Gu and Zach W. Hall},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={117},
  pages={841 - 847}
}
We have investigated the role of the immunoglobulin-binding protein (BiP) in the folding and assembly of subunits of the acetylcholine receptor (AChR) in COS cells and in C2 muscle cells. Immunoprecipitation in COS cells showed that alpha, beta, and delta subunits are associated with BiP. In the case of the alpha subunit, which first folds to acquire toxin-binding activity and is then assembled with the other subunits to form the AChR, BiP was associated only with a form that is unassembled and… CONTINUE READING

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Received for publication 9 December 1991 and in revised form 18

Received for publication 9 December 1991 and in revised form 18 • 1992

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