BiP-dependent export of cholera toxin from endoplasmic reticulum-derived microsomes.

@article{Winkeler2003BiPdependentEO,
  title={BiP-dependent export of cholera toxin from endoplasmic reticulum-derived microsomes.},
  author={Alexandra Winkeler and Daniela G{\"o}dderz and Volker Herzog and Anton Schmitz},
  journal={FEBS letters},
  year={2003},
  volume={554 3},
  pages={439-42}
}
Cholera toxin (CT) is transported from the cell surface to the endoplasmic reticulum (ER) from where it is translocated to the cytosol in a process depending on ATP and luminal ER proteins. To test whether the molecular chaperone BiP (heavy chain binding protein), which is an ER-luminal ATPase, was one of the required proteins the export of CT was analyzed using ER-derived CT-loaded microsomes. The resubstitution of extracted export-incompetent microsomes with purified BiP was sufficient to… CONTINUE READING

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