BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions.

@article{Behnke2015BiPAI,
  title={BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions.},
  author={Julia Behnke and Matthias J Feige and Linda M Hendershot},
  journal={Journal of molecular biology},
  year={2015},
  volume={427 7},
  pages={1589-608}
}
BiP (immunoglobulin heavy-chain binding protein) is the endoplasmic reticulum (ER) orthologue of the Hsp70 family of molecular chaperones and is intricately involved in most functions of this organelle through its interactions with a variety of substrates and regulatory proteins. Like all Hsp70 family members, the ability of BiP to bind and release unfolded proteins is tightly regulated by a cycle of ATP binding, hydrolysis, and nucleotide exchange. As a characteristic of the Hsp70 family… CONTINUE READING

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