Bi-stable neural state switches

  title={Bi-stable neural state switches},
  author={Andr{\'e} Berndt and Ofer Yizhar and Lisa A. Gunaydin and Peter Hegemann and Karl Deisseroth},
  journal={Nature Neuroscience},
Here we describe bi-stable channelrhodopsins that convert a brief pulse of light into a stable step in membrane potential. These molecularly engineered probes nevertheless retain millisecond-scale temporal precision. Photocurrents can be precisely initiated and terminated with different colors of light, but operate at vastly longer time scales than conventional channelrhodopsins as a result of modification at the C128 position that extends the lifetime of the open state. Because of their… CONTINUE READING
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