Bi-directional regulation between adiponectin and plasminogen activator-inhibitor-1 in 3T3-L1 cells.

@article{Komiya2014BidirectionalRB,
  title={Bi-directional regulation between adiponectin and plasminogen activator-inhibitor-1 in 3T3-L1 cells.},
  author={Masami Komiya and Gen Fujii and Mami Takahashi and Misato Shimura and Nobuharu Noma and Satomi Shimizu and Wakana Onuma and Michihiro Mutoh},
  journal={In vivo},
  year={2014},
  volume={28 1},
  pages={13-9}
}
BACKGROUND Adiponectin (APN) and plasminogen activator inhibitor-1 (Pai-1) are adipocytokines, and low levels of serum APN and high levels of PAI-1 are observed in obese patients. Moreover, both APN and Pai-1 are known to be involved in colorectal carcinogenesis. Recently, we demonstrated that serum Pai-1 levels are elevated in APN-deficient mice. We hypothesized that Pai-1 expression levels could be depressed by APN. Thus, we aimed to clarify the bi-directional regulatory mechanisms between… CONTINUE READING