Bi-directional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1

Abstract

MicroRNAs (miRNAs) originate from primary transcripts (pri-miRNAs) with characteristic stem-loop structures, and their accurate processing is required for the production of functional miRNAs. Here, using the pri-miR-166 family in Arabidopsis thaliana as a paradigm, we report the crucial role of pri-miRNA terminal loops in miRNA biogenesis. We found that… (More)
DOI: 10.1038/nsmb.2646

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