Bhc‐cNMPs as either Water‐Soluble or Membrane‐Permeant Photoreleasable Cyclic Nucleotides for both One‐ and Two‐Photon Excitation
@article{Furuta2004BhccNMPsAE,
title={Bhc‐cNMPs as either Water‐Soluble or Membrane‐Permeant Photoreleasable Cyclic Nucleotides for both One‐ and Two‐Photon Excitation},
author={Toshiaki Furuta and Hiroko Takeuchi and Masahiro Isozaki and Yasuhiro Takahashi and Makoto Kanehara and Masazumi Sugimoto and Takayoshi Watanabe and Kousei Noguchi and Timothy M. Dore and Takashi Kurahashi and Michiko Iwamura and Roger Tsien},
journal={ChemBioChem},
year={2004},
volume={5}
}Cyclic nucleoside monophosphates (cNMPs) play key roles in many cellular regulatory processes, such as growth, differentiation, motility, and gene expression. Caged derivatives that can be activated by irradiation could be powerful tools for studying such diverse functions of intracellular second messengers, since the spatiotemporal dynamics of these molecules can be controlled by irradiation with appropriately focused light. Here we report the synthesis, photochemistry, and biological testing…
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