Bfu-e Colony Growth in Response to Hydroxyurea: Correlation between in Vitro and in Vivo Fetal Hemoglobin Induction 158

@article{Yang1997BfueCG,
  title={Bfu-e Colony Growth in Response to Hydroxyurea: Correlation between in Vitro and in Vivo Fetal Hemoglobin Induction 158},
  author={Yoon Mo Yang and Betty S Pace and D L Kitchens and Samir K Ballas and Arvind Kumar Shah and B Surendra Baliga},
  journal={Pediatric Research},
  year={1997},
  volume={41},
  pages={778-778}
}
Patients with sickle-cell anemia treated with hydroxyurea may have significant reduction in frequency and severity of pain episodes. However, previous clinical trials show a variable response to hydroxyurea. Criteria which can be used to select patients who are likely to respond to hydroxyurea treatment would be useful. Our laboratory has previously demonstrated an inverse linear relationship between the total number of burst-forming unit-erythroid (BFU-E) colonies and fetal hemoglobin levels… CONTINUE READING

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