Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity.

@article{Mori2004BezafibrateinducedCO,
  title={Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity.},
  author={Yutaka Mori and Yoshiki Tokutate and Fumiki Oana and Akane Matsuzawa and Satoshi Akahane and Naoko Tajima},
  journal={Journal of atherosclerosis and thrombosis},
  year={2004},
  volume={11 4},
  pages={224-31}
}
The effect of short-term bezafibrate (BF) administration over time on the expression of UCP mRNA in the tissues was examined in Otsuka Long Evans Tokushima Fatty (OLETF) rats. Eight-week-old rats were divided into a high-dose (100 mg/kg) BF group (n = 15), a low-dose (10 mg/kg) BF group (n = 15) and a control group (n = 15), and followed for 14 days. Feed intake by the high-dose BF group increased significantly between days 10 and 14 of administration. Triglyceride, free fatty acid, and T(4… CONTINUE READING

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