Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins

@inproceedings{Nelson2013BeyondUT,
  title={Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins},
  author={David Evan Nelson and Suzanne J. Randle and Heike Laman},
  booktitle={Open biology},
  year={2013}
}
F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3 ubiquitin ligases. To date, 69 FBPs have been identified in humans, but ubiquitinated substrates have only been identified for a few, with the majority of FBPs remaining 'orphans'. In recent years, a growing body of work has identified non-canonical, SCF-independent roles for about 12% of the human FBPs. These atypical FBPs affect processes as diverse as transcription, cell cycle regulation, mitochondrial… CONTINUE READING

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