Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins

  title={Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins},
  author={David Evan Nelson and Suzanne J. Randle and Heike Laman},
  booktitle={Open biology},
F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3 ubiquitin ligases. To date, 69 FBPs have been identified in humans, but ubiquitinated substrates have only been identified for a few, with the majority of FBPs remaining 'orphans'. In recent years, a growing body of work has identified non-canonical, SCF-independent roles for about 12% of the human FBPs. These atypical FBPs affect processes as diverse as transcription, cell cycle regulation, mitochondrial… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 20 extracted citations


Publications referenced by this paper.
Showing 1-10 of 143 references

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 17 Excerpts
Highly Influenced

Ensembl 2013

P Flicek
Nucleic Acids Res • 2013

Similar Papers

Loading similar papers…