Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer

@inproceedings{Tsang2012BeyondTN,
  title={Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer},
  author={Ricson Y M Tsang and Rs. Finn},
  booktitle={British Journal of Cancer},
  year={2012}
}
The use of trastuzumab, a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) alteration present in 25 to 30% of breast cancers, has been associated with improved survival outcomes in both the adjuvant and metastatic settings. However, despite the robust clinical efficacy of trastuzumab in HER2-positive metastatic breast cancer (MBC), primary and secondary resistance remains a clinical challenge. Although lapatinib has demonstrated modest activity in this… CONTINUE READING
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Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer

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