Beyond the resistance: how novel neurobiological understandings of depression may lead to advanced treatment strategies.

Abstract

For patients with depression, antidepressant response rates are generally low and residual symptoms can increase the risk of relapse. Poor response may be linked to increased inflammatory cytokines and obesity. Specifically targeting inflammation with adjunct l-methylfolate treatment may help patients with depression finally achieve remission. In this Webcast, experts examine the multi-directional relationship between obesity, inflammation, and depression, consider preliminary data on genetic alleles, and review evidence using l-methylfolate as a targeted therapy.

DOI: 10.4088/JCP.12020wc3

Cite this paper

@article{Jain2012BeyondTR, title={Beyond the resistance: how novel neurobiological understandings of depression may lead to advanced treatment strategies.}, author={Rakesh K. Jain and Walter C Jackson}, journal={The Journal of clinical psychiatry}, year={2012}, volume={73 11}, pages={e30} }