Beyond the randomized clinical trial: the role of effectiveness studies in evaluating cardiovascular therapies.


Randomized clinical trials (RCTs) are familiar to most clinicians involved in the care of patients with cardiovascular disease. RCTs are the uncontested “gold standard” for establishing causation between a therapy and outcomes for a compelling reason: A large randomized experiment is the only study design that can guarantee that control and intervention… (More)
DOI: 10.1161/CIRCULATIONAHA.107.703579

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