Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression

@article{Massart2012BeyondTM,
  title={Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression},
  author={Renaud Massart and R. Mongeau and Laurence Lanfumey},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2012},
  volume={367},
  pages={2485 - 2494}
}
The monoamine hypothesis of depression has dominated our understanding of both the pathophysiology of depression and the action of pharmacological treatments for the last decades, and it has led to the production of several generations of antidepressant agents. However, there are serious limitations to the current monoamine theory, and additional mechanisms, including hypothalamic–pituitary–adrenal (HPA) axis dysfunctions, as well as neurodegenerative and inflammatory alterations, are… 

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