Beyond the intention-to-treat in comparative effectiveness research.


BACKGROUND The intention-to-treat comparison is the primary, if not the only, analytic approach of many randomized clinical trials. PURPOSE To review the shortcomings of intention-to-treat analyses, and of 'as treated' and 'per protocol' analyses as commonly implemented, with an emphasis on problems that are especially relevant for comparative… (More)
DOI: 10.1177/1740774511420743