Beyond the brush border: NHERF4 blazes new NHERF turf.

  title={Beyond the brush border: NHERF4 blazes new NHERF turf.},
  author={William R. Thelin and Caleb A Hodson and Sharon L. Milgram},
  journal={The Journal of physiology},
  volume={567 Pt 1},
The Na exchanger regulatory factor (NHERF) family of epithelial-enriched PDZ domain scaffolding proteins plays important roles in maintaining and regulating epithelial cell function. The NHERFs exhibit some overlap in tissue distribution and binding partners, suggesting redundant functions. Yet, it is clear that each NHERF protein exhibits distinct properties, translating into unique cellular functions. The work summarized in this review suggests the most recently identified family member… CONTINUE READING

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