1,103 Citations
Functional implications of genome topology
- BiologyNature Structural &Molecular Biology
- 2013
The emerging picture is one of extensive self-enforcing feedback between activity and spatial organization of the genome, suggestive of a self-organizing and self-perpetuating system that uses epigenetic dynamics to regulate genome function in response to regulatory cues and to propagate cell-fate memory.
Higher-order genome organization in human disease.
- BiologyCold Spring Harbor perspectives in biology
- 2010
Mutations and transcriptional misregulation of several global genome organizers are linked to human diseases and global alterations in chromatin structure are emerging as key players in maintenance of genome stability, aging, and the formation of cancer translocations.
Three-dimensional organization and dynamics of the genome
- BiologyCell Biology and Toxicology
- 2018
In this review, the current view of the genome architecture on the scales ranging from chromatin loops to the whole genome is summarized and links between genome reorganization and various genomic processes, such as chromosome X inactivation and cell differentiation, are described.
Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations
- BiologyBMC biophysics
- 2011
Results are reviewed and some additional insights are provided that elucidate the relationship between structure and function at different hierarchical levels of genome organization.
Understanding Spatial Genome Organization: Methods and Insights
- BiologyGenom. Proteom. Bioinform.
- 2016
Molecular Cell Review The Hierarchy of the 3 D Genome
- Biology
- 2013
The experimental and theoretical data on this hierarchy of structures and a key role for the recently discovered topologically associating domains are reviewed and proposed.
Dynamics and interplay of nuclear architecture, genome organization, and gene expression.
- BiologyGenes & development
- 2007
Recent studies that have provided exciting insight into the interplay between nuclear architecture, genome organization, and gene expression are discussed.
Long-Range Chromatin Interactions.
- BiologyCold Spring Harbor perspectives in biology
- 2015
The nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance are discussed.
References
SHOWING 1-10 OF 263 REFERENCES
Concepts in nuclear architecture
- BiologyBioEssays : news and reviews in molecular, cellular and developmental biology
- 2005
An overview of some of the emerging concepts in the study of in vivo genome organization and function is given.
Predicting three-dimensional genome structure from transcriptional activity
- BiologyNature Genetics
- 2002
A model for the three-dimensional structure of all genomes is presented, based on the structure of the bacterial nucleoid, where RNA polymerases cluster and loop the DNA, to predict how genomes are folded in the cell from the primary DNA sequence.
Transcriptional control thrown for a loop.
- BiologyCurrent opinion in genetics & development
- 2006
Replication and transcription: Shaping the landscape of the genome
- BiologyNature Reviews Genetics
- 2005
As the relationship between nuclear structure and function begins to unfold, a picture is emerging of a dynamic landscape that is centred on the two main processes that execute the regulated use andâŠ
Gene Order and Dynamic Domains
- BiologyScience
- 2004
Contrary to prevailing notions in this postgenomic era, the bacteriophage λ, a paragon of simplicity, may still have a few things to teach us with respect to these facets of nonrandom genomes.
Nuclear Organization of Mammalian Genomes
- BiologyThe Journal of cell biology
- 1999
It is shown that distinct higher order compartments whose DNA displays a specific replication timing are stably maintained during all interphase stages and have no transcriptional activity detectable by BrUTP pulse labeling and show no evidence of transcriptional competence.
Nuclear organization of mammalian genomes : Polar chromosome territories build up functionally distinct higher order compartments
- Biology
- 1999
It is shown that distinct higher order compartments whose DNA displays a specific replication timing are stably maintained during all interphase stages and have no transcriptional activity detectable by BrUTP pulse labeling and show no evidence of transcriptional competence.
Spatial genome organization in the formation of chromosomal translocations.
- BiologySeminars in cancer biology
- 2007
Systems biology in the cell nucleus
- BiologyJournal of Cell Science
- 2005
Converging technological developments in genomics, proteomics, dynamics and computation are now leading towards an integrated biological understanding of genome biology and nuclear function.