Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon*

@article{Young2010BeyondTC,
  title={Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon*},
  author={T. Young and P. Schultz},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={11039 - 11044}
}
The ability to genetically encode unnatural amino acids beyond the common 20 has allowed unprecedented control over the chemical structures of recombinantly expressed proteins. Orthogonal aminoacyl-tRNA synthetase/tRNA pairs have been used together with nonsense, rare, or 4-bp codons to incorporate >50 unnatural amino acids into proteins in Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, and mammalian cell lines. This has allowed the expression of proteins containing amino acids… Expand
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