Beyond the 3′ end: experimental validation of extended transcript isoforms

@inproceedings{Moucadel2007BeyondT3,
  title={Beyond the 3′ end: experimental validation of extended transcript isoforms},
  author={Virginie Moucadel and Fabrice Lopez and Takeshi Ara and Philippe Benech and Daniel Gautheret},
  booktitle={Nucleic acids research},
  year={2007}
}
High throughput EST and full-length cDNA sequencing have revealed extensive variations at the 3' ends of mammalian transcripts. Whether all of these changes are biologically meaningful has been the subject of controversy, as such, results may reflect in part transcription or polyadenylation leakage. We selected here a set of tandem poly(A) sites predicted from EST/cDNA sequence analysis that (i) are conserved between human and mouse, (ii) produce alternative 3' isoforms with unusual size… CONTINUE READING
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