Beyond serotonin: newer antidepressants in the future

@article{Rakesh2017BeyondSN,
  title={Beyond serotonin: newer antidepressants in the future},
  author={Gopalkumar Rakesh and Chi-Un Pae and Prakash S. Masand},
  journal={Expert Review of Neurotherapeutics},
  year={2017},
  volume={17},
  pages={777 - 790}
}
ABSTRACT Introduction: There are numerous antidepressants for the treatment of major depressive disorder (MDD) on the market. However, inadequate treatment response, therapeutic lag between drug administration and the onset of clinical improvement, and safety/tolerability issues with the use of contemporary antidepressants have accelerated the search for newer antidepressants with novel mechanisms of action. Areas covered: The authors review novel antidepressants with rapid efficacy for diverse… 
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13 Citations

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets

It is suggested that drug targeting different neurobiological systems should be able to restore normal function but must also promote resilience to reduce the long-term vulnerability to recurrent depressive episodes.

Novel Pathways in the Treatment of Major Depression: Focus on the Glutamatergic System.

The most advanced knowledge on the involvement of glutamatergic system in the molecular mechanisms at the basis of depression pathophysiology are discussed, as well as the glutamate-based therapeutic strategies currently suggested to optimize depression treatment (e.g., ketamine).

The effects of intramuscular administration of scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled trial

It is found that scopolamine was not associated with a significantly faster antidepressant response rate compared to placebo, and the main focus of this study is to detect the capacity of the rapid-onset efficacy of such a treatment option.

"Novel Psychopharmacology for Depressive Disorders".

The present chapter briefly assesses the most promising agents, focusing on non-monoamine-targeting compounds, namely, the glutamate antagonist ketamine and its enantiomer esketamine.

A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial

  • Changsu HanSheng-Min Wang A. Serretti
  • Psychology, Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2018
It is demonstrated that PGATx may be a better treatment option in the treatment of MDD in terms of effectiveness and tolerability; however, study shortcomings may limit a generalization.

Astrocytes activation contributes to the antidepressant-like effect of ketamine but not scopolamine

Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model

The observations suggest that biased agonist targeting of cortical 5-HT1A receptors constitutes a promising strategy to achieve rapid-acting and sustained antidepressant effects.

Metabolic effects of light deprivation in the prefrontal cortex of rats with depression-like behavior: In vivo proton magnetic resonance spectroscopy at 7T

Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction

Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques

The incidence of ketamine-induced neuromuscular reactivity is age related but not affected by the estrous cycle in female rhesus macaques, suggesting a central nervous system (CNS) mechanism for ketamines-associated neuromUScular reactions.

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