Beyond reversal: a critical role for human orbitofrontal cortex in flexible learning from probabilistic feedback.

@article{Tsuchida2010BeyondRA,
  title={Beyond reversal: a critical role for human orbitofrontal cortex in flexible learning from probabilistic feedback.},
  author={Ami Tsuchida and Bradley B. Doll and Lesley K. Fellows},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 50},
  pages={16868-75}
}
Damage to the orbitofrontal cortex (OFC) has been linked to impaired reinforcement processing and maladaptive behavior in changing environments across species. Flexible stimulus-outcome learning, canonically captured by reversal learning tasks, has been shown to rely critically on OFC in rats, monkeys, and humans. However, the precise role of OFC in this learning remains unclear. Furthermore, whether other frontal regions also contribute has not been definitively established, particularly in… CONTINUE READING

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