Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy.

@article{SnchezNio2012BeyondPV,
  title={Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy.},
  author={Mar{\'i}a-Dolores S{\'a}nchez-Ni{\~n}o and Milica Bozic and Elizabeth C{\'o}rdoba-Lan{\'u}s and Petya Valcheva and Olga Gracia and Merc{\'e} Ibarz and Elvira Fern{\'a}ndez and Juan F Navarro-Gonz{\'a}lez and Alberto Ortiz and Jos{\'e} M Valdivielso},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={302 6},
  pages={F647-57}
}
Local inflammation is thought to contribute to the progression of diabetic nephropathy. The vitamin D receptor (VDR) activator paricalcitol has an antiproteinuric effect in human diabetic nephropathy at high doses. We have explored potential anti-inflammatory effects of VDR activator doses that do not modulate proteinuria in an experimental model of diabetic nephropathy to gain insights into potential benefits of VDR activators in those patients whose proteinuria is not decreased by this… CONTINUE READING
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