Beyond polymer polarity: how the cytoskeleton builds a polarized cell

  title={Beyond polymer polarity: how the cytoskeleton builds a polarized cell},
  author={Rong Li and Gregg G. Gundersen},
  journal={Nature Reviews Molecular Cell Biology},
Cell polarity relies on the asymmetric organization of cellular components and structures. Actin and microtubules are well suited to provide the structural basis for cell polarization because of their inherent structural polarity along the polymer lattices and intrinsic dynamics that allow them to respond rapidly to polarity cues. In general, the actin cytoskeleton drives the symmetry-breaking process that enables the establishment of a polarized distribution of regulatory molecules, whereas… CONTINUE READING
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