Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells

@inproceedings{Cerundolo2014BeyondMA,
  title={Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells},
  author={Vincenzo W Cerundolo and Mark M. Davis},
  booktitle={Nature Biotechnology},
  year={2014}
}
Adaptive immune responses often begin with the formation of a molecular complex between a T-cell receptor (TCR) and a peptide antigen bound to a major histocompatibility complex (MHC) molecule. These complexes are highly variable, however, due to the polymorphism of MHC genes, the random, inexact recombination of TCR gene segments, and the vast array of possible self and pathogen peptide antigens. As a result, it has been very difficult to comprehensively study the TCR repertoire or identify… CONTINUE READING
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Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells

  • D Weiskopf
  • Proc. Natl. Acad. Sci. USA 110,
  • 2013

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