Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection.

@article{Boelen2011BeyondLP,
  title={Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection.},
  author={Anita Boelen and Joan Kwakkel and Eric Fliers},
  journal={Endocrine reviews},
  year={2011},
  volume={32 5},
  pages={670-93}
}
Decreased serum thyroid hormone concentrations in severely ill patients were first reported in the 1970s, but the functional meaning of the observed changes in thyroid hormone levels, together known as nonthyroidal illness syndrome (NTIS), remains enigmatic. Although the common view was that NTIS results in overall down-regulation of metabolism in order to save energy, recent work has shown a more complex picture. NTIS comprises marked variation in transcriptional and translational activity of… CONTINUE READING

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MuscleNo subtypeMyopathy
For instance , changes in thyroid hormone metabolism in muscle during critical illness may be relevant for the pathogenesis of myopathy associated with prolonged ventilator dependence .
MyopathyNo subtypeMuscle
For instance , changes in thyroid hormone metabolism in muscle during critical illness may be relevant for the pathogenesis of myopathy associated with prolonged ventilator dependence .
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